Yaoxue Xuebao

YX-18-11-2024-2126
| Yaoxue Xuebao (ISSN:0513-4870)

Advances of artificial intelligence technology in the discovery and optimization of lead compounds

Artificial intelligence (AI) encompasses a broad spectrum of techniques that have been utilized by pharmaceutical companies for decades, including machine learning, deep learning, and other advanced computational methods. These innovations have unlocked unprecedented opportunities for the acceleration of drug discovery and delivery, the optimization of treatment regimens, and the improvement of patient outcomes. AI is swiftly transforming the pharmaceutical industry, revolutionizing everything from drug development and discovery to personalized medicine, including target identification and

YX-18-11-2024-2125
| Yaoxue Xuebao (ISSN:0513-4870)

Design, synthesis and antidepressant activity of novel genipin derivatives

Genipin has been the focus of research as a multifunctional compound for the treatment of pathogenic diseases. However, hepatotoxicity caused by oral genipin raises concerns about its safety. To obtain novel derivatives with low toxicity and efficacy, we synthesized methylgenipin (MG), a new compound, using structural modification, and investigated the safety of MG administration. The results showed that the LD50 of oral MG was higher than 1000 mg/kg, no mice died or were poisoned during the experiment in the treatment group, and there was no significant difference in biochemical parameters

YX-18-11-2024-2124
| Yaoxue Xuebao (ISSN:0513-4870)

Advances in gastric retention drug delivery system

Oral absorption of drugs with narrow absorption window in the upper small intestine shows poor bioavailability with conventional dosage forms due short residence time. To overcome this restriction and to increase the bioavailability of these drugs, controlled drug delivery systems with a prolonged residence time in the stomach can be used. Gastric retention drug delivery system can be used to prolonged residence times of the drug in the upper part of the gastrointestinal tract. The current review deals with formulation developments of gastric retentive drug delivery systems which is prolong

YX-18-11-2024-2123
| Yaoxue Xuebao (ISSN:0513-4870)

Recent progress of CDK5 inhibitors targeting ATP active sites

Protein kinases have essential responsibilities in controlling several cellular processes, and their abnormal regulation is strongly related to the development of cancer. The implementation of protein kinase inhibitors has significantly transformed cancer therapy by modifying treatment strategies. These inhibitors have received substantial FDA clearance in recent decades. Protein kinases have emerged as primary objectives for therapeutic interventions, particularly in the context of cancer treatment. At present, 69 therapeutics have been approved by the FDA that target approximately 24 prot

YX-18-11-2024-2122
| Yaoxue Xuebao (ISSN:0513-4870)

An overview of disease treatment strategies targeting the alternative splicing of pre-mRNA

Alternative splicing of pre-messenger RNA (pre-mRNA) is a crucial mechanism for the diversity of the human transcriptome and proteome. Alternative splicing is a complex gene regulation process. Whole-transcriptome analysis shows that 95% of human exonic genes are alternatively spliced, involving various cis-acting elements and trans-acting factors. Any changes in any component or step may cause erroneous splicing events and lead to the occurrence of various related diseases. In addition to gene replacement therapy that directly changes the splicing results, RNA splicing modification is expe

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Yaoxue Xuebao

Advances of artificial intelligence technology in the discovery and optimization of lead compounds

Design, synthesis and antidepressant activity of novel genipin derivatives

Advances in gastric retention drug delivery system

Recent progress of CDK5 inhibitors targeting ATP active sites

An overview of disease treatment strategies targeting the alternative splicing of pre-mRNA

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