Yaoxue Xuebao

YX-25-02-2025-2146
| Yaoxue Xuebao (ISSN:0513-4870)

Preliminary study of the transport and absorption mechanism of Astragalus polysaccharide-II on M cells

Astragali radix (AR) is one of the most widely used traditional Chinese herbal medicines. Modern pharmacological studies and clinical practices indicate that AR possesses various biological functions, including potent immunomodulation, antioxidant, anti-inflammation and antitumor activities. To date, more than 200 chemical constituents have been isolated and identified from AR. Among them, isoflavonoids, saponins and polysaccharides are the three main types of beneficial compounds responsible for its pharmacological activities and therapeutic efficacy. After ingestion of AR, the metabolism

YX-25-02-2025-2145
| Yaoxue Xuebao (ISSN:0513-4870)

Advances in host protease-mediated influenza virus entry

TMPRSS2, a human transmembrane protease enzyme, plays a crucial role in the spread of certain viruses, including influenza and coronaviruses. This enzyme promotes viral infection by cleaving viral glycoproteins, which helps viruses like SARS-CoV-2 and influenza A enter cells more effectively. Genetic differences in TMPRSS2 may affect people’s susceptibility to COVID-19, underscoring the need for studies that consider diverse populations. Beyond infectious diseases, TMPRSS2 has also been linked to some cancers, suggesting it could be a valuable target for drug development. This review

YX-25-02-2025-2144
| Yaoxue Xuebao (ISSN:0513-4870)

Cloning and interacted protein identification of AP1 homologous gene from Lonicera macranthoides

To clone the AP1 (Lm-XL-AP1) gene from a Special Variant Varieties of Lonicera macranthoides "Xianglei", and to analyze its bioinformatics and spatio-temporal expression. Amplifing the full length of Lm-XL-AP1 gene by RACE technique, using bioinformatics method to analyze homology and similarity of the gene, predicting the coding protein and analyzing the various physical and chemical properties. The expression of the gene in different parts of Lonicera macranthoides Special Variant Varieties was detected by fluorescence quantitative PCR (qRT-PCR). The AP1 gene, containing a 729 b

YX-11-12-2024-2143
| Yaoxue Xuebao (ISSN:0513-4870)

Validation of the Russian-Language Version of the Adolescent Computer Games Addiction Assessment Questionnaire (Game Addiction Scale for Adolescents)

With the rapid growth of the video game industry and the increasing availability of online gaming worldwide, problematic gaming behaviors are on the rise, with significant psychosocial and somatic consequences. The aim of this study was to translate and validate the Russian version of the Game Addiction Scale for Adolescents (GASA), a brief 7-item psychometric instrument to identify addiction to computer games in adolescents. The GASA questionnaire was translated into Russian and tested on a sample of 2380 adolescents ages 11- 19 from schools in Krasnoyarsk. Internal consistency, factor str

YX-18-11-2024-2142
| Yaoxue Xuebao (ISSN:0513-4870)

2-(2-Phenylethyl)chromones from agarwood of Aquilaria agallocha and their inhibitory activity against KRAS mutant NSCLC

Two new 2-(2-phenylethyl)chromone derivatives (1–2), comprising 5,6,7,8-tetrahydro-2-(2-phenylethyl)chromone and benzylacetone moieties, together with one new 2-(2-phenylethenyl)chromone (3) were isolated from the ethyl acetate extraction of agarwood originated from Gyrinops salicifolia Ridl. All structures were unambiguously elucidated on the basis of 1D and 2D NMR spectra as well as by HRESIMS data. All isolated compounds were tested for acetylcholinesterase (AChE) inhibitory activity and cytotoxic activity against human myeloid leukemia cell line (K562). However, none of the compou

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Yaoxue Xuebao

Preliminary study of the transport and absorption mechanism of Astragalus polysaccharide-II on M cells

Advances in host protease-mediated influenza virus entry

Cloning and interacted protein identification of AP1 homologous gene from Lonicera macranthoides

Validation of the Russian-Language Version of the Adolescent Computer Games Addiction Assessment Questionnaire (Game Addiction Scale for Adolescents)

2-(2-Phenylethyl)chromones from agarwood of Aquilaria agallocha and their inhibitory activity against KRAS mutant NSCLC

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