Advances in gastric retention drug delivery system

Oral absorption of drugs with narrow absorption window in the upper small intestine shows poor bioavailability with conventional dosage forms due short residence time. To overcome this restriction and to increase the bioavailability of these drugs, controlled drug delivery systems with a prolonged residence time in the stomach can be used. Gastric retention drug delivery system can be used to prolonged residence times of the drug in the upper part of the gastrointestinal tract. The current review deals with formulation developments of gastric retentive drug delivery systems which is prolonged residence time and enhancing oral bioavailability of the drugs. This review discusses on gastroretentive delivery system especially designed against H. pylori, including patented delivery systems and marketed products, and their advantages and future potential for gastric retention drug delivery systems are discussed.