Yaoxue Xuebao

YX-18-11-2024-2125
| Yaoxue Xuebao (ISSN:0513-4870)

Design, synthesis and antidepressant activity of novel genipin derivatives

Genipin has been the focus of research as a multifunctional compound for the treatment of pathogenic diseases. However, hepatotoxicity caused by oral genipin raises concerns about its safety. To obtain novel derivatives with low toxicity and efficacy, we synthesized methylgenipin (MG), a new compound, using structural modification, and investigated the safety of MG administration. The results showed that the LD50 of oral MG was higher than 1000 mg/kg, no mice died or were poisoned during the experiment in the treatment group, and there was no significant difference in biochemical parameters

YX-18-11-2024-2124
| Yaoxue Xuebao (ISSN:0513-4870)

Advances in gastric retention drug delivery system

Oral absorption of drugs with narrow absorption window in the upper small intestine shows poor bioavailability with conventional dosage forms due short residence time. To overcome this restriction and to increase the bioavailability of these drugs, controlled drug delivery systems with a prolonged residence time in the stomach can be used. Gastric retention drug delivery system can be used to prolonged residence times of the drug in the upper part of the gastrointestinal tract. The current review deals with formulation developments of gastric retentive drug delivery systems which is prolong

YX-18-11-2024-2123
| Yaoxue Xuebao (ISSN:0513-4870)

Recent progress of CDK5 inhibitors targeting ATP active sites

Protein kinases have essential responsibilities in controlling several cellular processes, and their abnormal regulation is strongly related to the development of cancer. The implementation of protein kinase inhibitors has significantly transformed cancer therapy by modifying treatment strategies. These inhibitors have received substantial FDA clearance in recent decades. Protein kinases have emerged as primary objectives for therapeutic interventions, particularly in the context of cancer treatment. At present, 69 therapeutics have been approved by the FDA that target approximately 24 prot

YX-18-11-2024-2122
| Yaoxue Xuebao (ISSN:0513-4870)

An overview of disease treatment strategies targeting the alternative splicing of pre-mRNA

Alternative splicing of pre-messenger RNA (pre-mRNA) is a crucial mechanism for the diversity of the human transcriptome and proteome. Alternative splicing is a complex gene regulation process. Whole-transcriptome analysis shows that 95% of human exonic genes are alternatively spliced, involving various cis-acting elements and trans-acting factors. Any changes in any component or step may cause erroneous splicing events and lead to the occurrence of various related diseases. In addition to gene replacement therapy that directly changes the splicing results, RNA splicing modification is expe

YX-18-11-2024-2121
| Yaoxue Xuebao (ISSN:0513-4870)

Pharmacokinetic effects of metformin hydrochloride, food and alcohol on Ramulus Mori (Sangzhi) alkaloids

Ramulus Mori (Sangzhi) alkaloids (SZ-A) are a group of polyhydroxy alkaloids extracted and isolated from the traditional Chinese medicine mulberry twig, which is mainly used for the treatment of type 2 diabetes mellitus (T2DM). In addition to acting as a glycosidase inhibitor in the small intestine after oral administration, SZ-A can also be absorbed into blood and widely distributed to target organs related to diabetes, exerting multiple pharmacological effects. It is important to elucidate the possible pharmacokinetic influences of SZ-A for its clinical rational applications, such as drug

Yaoxue Xuebao

Dear respected authors,

If you can't find our response by email, please check your spam box as well as communicate with us to the following mail as well: journalpublication435@gmail.com

Yaoxue Xuebao

Yaoxue Xuebao

Pharmacology

Toxicology and Pharmaceutics

General Pharmacology

Toxicology and Pharmaceutics Biochemistry

Genetics and Molecular Biology

Molecular Medicine

Yaoxue Xuebao

Design, synthesis and antidepressant activity of novel genipin derivatives

Advances in gastric retention drug delivery system

Recent progress of CDK5 inhibitors targeting ATP active sites

An overview of disease treatment strategies targeting the alternative splicing of pre-mRNA

Pharmacokinetic effects of metformin hydrochloride, food and alcohol on Ramulus Mori (Sangzhi) alkaloids

Information

Guidelines

Contact Us

All rights reserved | © 2024 Yaoxue Xuebao (ISSN:0513-4870).