Yaoxue Xuebao

YX-18-11-2024-2133
| Yaoxue Xuebao (ISSN:0513-4870)

Preparation and in vitro-in vivo evaluation of suvorexant orodispersible films

The first and only antidepressant drug on the market with solid proof of clinically significant serotonin and noradrenaline reuptake inhibition is clomipramine (CLP). However, significant first-pass metabolism reduces its absorption to less than 62%. It is heavily protein-bound and broadly dispersed across the body (9–25 L/kg volume of distribution). The purpose of this research was to formulate CLP orodispersible tablets that immediately enable the drug to enter the bloodstream and bypass systemic portal circulation to improve its bioavailability. A factorial design was employed usin

YX-18-11-2024-2132
| Yaoxue Xuebao (ISSN:0513-4870)

Identification and expression analysis of AP2/ERF gene family in Artemisia argyi

Growth-regulating factor (GRF) genes in Artemisia argyi were identified and analyzed. Bioinformatic analysis on the physiochemical properties, structure, and evolution of the GRF genes, as well as their expressions in different tissues under stresses, of A. argyi was conducted using qRT-PCR. SeventeenAsGRFs were hydrophilic proteins in the phylogenetic evolutionary tree of 4 subfamilies. Those genes of same clade in the evolutionary tree contained a similar or same conserved motif. The members were randomly distributed on 11 chromosomes with promoters of multiple stress- and hormone-respons

YX-18-11-2024-2131
| Yaoxue Xuebao (ISSN:0513-4870)

Pharmacokinetics of PROTACs and their research progress in disease treatment

Proteolysis-targeting chimera (PROTAC) technology is a groundbreaking therapeutic approach with significant clinical potential for degrading disease-inducing proteins within targeted cells. However, challenges related to insufficient target selectivity raise concerns about PROTAC toxicity toward normal cells. To address this issue, researchers are modifying PROTACs using various approaches to enhance their target specificity. This review highlights innovative optically controlled PROTACs as anti-cancer therapies currently used in clinical practice and explores the challenges associated with

YX-18-11-2024-2130
| Yaoxue Xuebao (ISSN:0513-4870)

Development of analgesic drugs targeting Nav1.7: advances in clinical trials and discovery of selective inhibitors

Chronic pain is a widespread disorder affecting millions of people and is insufficiently addressed by current classes of analgesics due to significant long-term or high dosage side effects. A promising approach that was recently proposed involves the systemic inhibition of the voltage-gated sodium channel Nav1.7, capable of cancelling pain perception completely. Notwithstanding numerous attempts, currently no drugs have been approved for the inhibition of Nav1.7. The task is complicated by the difficulty of creating a selective drug for Nav1.7, and avoiding binding to the many human paralog

YX-18-11-2024-2129
| Yaoxue Xuebao (ISSN:0513-4870)

Exploration of the antioxidant role and mechanism of Astragalus membranaceus based on a glucose-induced Caenorhabditis elegans model

Astragali radix is a traditional medicinal herb with a long history and wide application. It is frequently used in prescriptions with other medicinal materials to replenish Qi. According to the classics of traditional Chinese medicine, Astragali radix is attributed with properties such as Qi replenishing and surface solidifying, sore healing and muscle generating, and inducing diuresis to reduce edema. Modern pharmacological studies have demonstrated that some extracts and active ingredients in Astragali radix function as antioxidants. The polysaccharides, saponins, and flavonoids in Astrag

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Toxicology and Pharmaceutics

General Pharmacology

Toxicology and Pharmaceutics Biochemistry

Genetics and Molecular Biology

Molecular Medicine

Yaoxue Xuebao

Preparation and in vitro-in vivo evaluation of suvorexant orodispersible films

Identification and expression analysis of AP2/ERF gene family in Artemisia argyi

Pharmacokinetics of PROTACs and their research progress in disease treatment

Development of analgesic drugs targeting Nav1.7: advances in clinical trials and discovery of selective inhibitors

Exploration of the antioxidant role and mechanism of Astragalus membranaceus based on a glucose-induced Caenorhabditis elegans model

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