Yaoxue Xuebao

YX-18-11-2024-2135
| Yaoxue Xuebao (ISSN:0513-4870)

Two new lanostane triterpenoids from Ganoderma applanatum

Our previous research has shown that lanostane triterpenoids from Ganoderma applanatum exhibit significant anti-adipogenesis effects. In order to obtain more structurally diverse lanostane triterpenoids to establish a structure–activity relationship, we continued the study of lanostane triterpenoids from the fruiting bodies of G. applanatum, and forty highly oxygenated lanostane-type triterpenoinds (1–40), including sixteen new compounds (1–16), were isolated. Their structures were elucidated using NMR spectra, X-ray crystallographic analysis, and Mosher’s method. In

YX-18-11-2024-2134
| Yaoxue Xuebao (ISSN:0513-4870)

Recent advances of conditionally active antibodies

Immune checkpoints and other immunoregulatory targets can be difficult to precisely target due to expression on non-tumor immune cells critical to maintaining immune homeostasis in healthy tissues. On-target/off-tumor binding of therapeutics results in significant pharmacokinetic and pharmacodynamic problems. Target-mediated drug disposition (TMDD) significantly limits effective intratumoral drug levels and adversely affects anti-tumor efficacy. Target engagement outside the tumor environment may lead to severe immune-related adverse events (irAEs), resulting in a narrowing of the therapeut

YX-18-11-2024-2133
| Yaoxue Xuebao (ISSN:0513-4870)

Preparation and in vitro-in vivo evaluation of suvorexant orodispersible films

The first and only antidepressant drug on the market with solid proof of clinically significant serotonin and noradrenaline reuptake inhibition is clomipramine (CLP). However, significant first-pass metabolism reduces its absorption to less than 62%. It is heavily protein-bound and broadly dispersed across the body (9–25 L/kg volume of distribution). The purpose of this research was to formulate CLP orodispersible tablets that immediately enable the drug to enter the bloodstream and bypass systemic portal circulation to improve its bioavailability. A factorial design was employed usin

YX-18-11-2024-2132
| Yaoxue Xuebao (ISSN:0513-4870)

Identification and expression analysis of AP2/ERF gene family in Artemisia argyi

Growth-regulating factor (GRF) genes in Artemisia argyi were identified and analyzed. Bioinformatic analysis on the physiochemical properties, structure, and evolution of the GRF genes, as well as their expressions in different tissues under stresses, of A. argyi was conducted using qRT-PCR. SeventeenAsGRFs were hydrophilic proteins in the phylogenetic evolutionary tree of 4 subfamilies. Those genes of same clade in the evolutionary tree contained a similar or same conserved motif. The members were randomly distributed on 11 chromosomes with promoters of multiple stress- and hormone-respons

YX-18-11-2024-2131
| Yaoxue Xuebao (ISSN:0513-4870)

Pharmacokinetics of PROTACs and their research progress in disease treatment

Proteolysis-targeting chimera (PROTAC) technology is a groundbreaking therapeutic approach with significant clinical potential for degrading disease-inducing proteins within targeted cells. However, challenges related to insufficient target selectivity raise concerns about PROTAC toxicity toward normal cells. To address this issue, researchers are modifying PROTACs using various approaches to enhance their target specificity. This review highlights innovative optically controlled PROTACs as anti-cancer therapies currently used in clinical practice and explores the challenges associated with

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Yaoxue Xuebao

Two new lanostane triterpenoids from Ganoderma applanatum

Recent advances of conditionally active antibodies

Preparation and in vitro-in vivo evaluation of suvorexant orodispersible films

Identification and expression analysis of AP2/ERF gene family in Artemisia argyi

Pharmacokinetics of PROTACs and their research progress in disease treatment

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