Yaoxue Xuebao

YX-18-11-2024-2140
| Yaoxue Xuebao (ISSN:0513-4870)

Metabolomic study of the improvement of nitazoxanide on Western-diet induced hepatic steatosis in ApoE-/- mice

Nonalcoholic fatty liver disease (NAFLD) is a major public health problem worldwide. NAFLD ranges in severity from benign steatosis to nonalcoholic steatohepatitis (NASH), cirrhosis, and primary hepatocellular cancer (HCC). Obesity and type 2 diabetes mellitus (T2DM) are strongly associated with NAFLD, and the western diet (WD) is a major contributor to the onset and progression of these chronic diseases. Our aim was to use a lipidomic approach to identify potential lipid mediators of diet-induced NASH. We previously used a preclinical mouse (low density lipoprotein receptor null mouse, Ldl

YX-18-11-2024-2139
| Yaoxue Xuebao (ISSN:0513-4870)

Research progress of nanomedical drug delivery system based on aerobic glycolytic regulation for tumor therapy

Chemotherapy together with surgery and/or radiotherapy are the most common therapeutic methods for treating cancer. However, the off-target effects of chemotherapy are known to produce side effects and dose-limiting toxicities. Novel delivery platforms based on natural and synthetic polymers with enhanced pharmacokinetic and therapeutic potential for the treatment of cancer have grown tremendously over the past 10 years. Polymers can facilitate selective targeting, enhance and prolong circulation, improve delivery, and provide the controlled release of cargos through various mechanisms, inc

YX-18-11-2024-2138
| Yaoxue Xuebao (ISSN:0513-4870)

Analysis of the mechanisms of Guanxinning Tablet for antithrombotic and microthrombotic effects caused by COVID-19 based on network pharmacology

Chuanxiong rhizoma (CX) has been utilized for centuries as a traditional herb to treat blood stasis syndromes. However, the pharmacological mechanisms are still not completely revealed. This research was aimed at exploring the molecular mechanisms of CX treatment for thrombosis. Network pharmacology was used to predict the potential anti-thrombosis mechanism after correlating the targets of active components with targets of thrombosis. Furthermore, we verified the mechanism of using CX to treat thrombosis via molecular docking and in vitro experiments. Network pharmacology results showed th

YX-18-11-2024-2137
| Yaoxue Xuebao (ISSN:0513-4870)

The effect and mechanism of Lycium barbarum leaves on D-galactose-induced cataract in rats based on metabolomics

The aim of this study was to investigate the effects of Lycium barbarum Polysaccharide (LBP) on alcohol-induced liver damage in rats. A total of 36 rats were divided into control, ethanol and ethanol + LBP groups. Rats in the ethanol group were fed 7 g ethanol/kg body weight by gastric infusion, three times a day, for 30 consecutive days, while rats in the control group received the same volume of physiological saline instead of ethanol, and rats in ethanol + LBP group were fed both ethanol (7 g/kg body weight) and LBP (300 mg/Kg body weight/day). Alcoholic liver injury was examined by seru

YX-18-11-2024-2136
| Yaoxue Xuebao (ISSN:0513-4870)

Chemical constituents of dichloromethane extract from the stems of Ephedra intermedia

Six new compounds, (7R,8S,8′R)-balanophorone (1), (7′S,8′R,8R)-yunnanensin A (2), (3S)-thunberginol C (3), (8R,8′R)-maninsigin B (4), (7S,8R)-4,7,8-dihydroxy-9,9-dimethyl-chroman (5), and 4-hydroxy-1-(4-hydroxy-3-methoxyphenyl)butan-1-one (6), along with eight known compounds (7–14), were isolated from the herbaceous stems of Ephedra intermedia Schrenket C. A. Meyer. Their structures were elucidated based on their spectroscopic (MS, NMR, IR, and UV) data, and their absolute configurations were determined by comparing their calculated and experimental electronic

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Molecular Medicine

Yaoxue Xuebao

Metabolomic study of the improvement of nitazoxanide on Western-diet induced hepatic steatosis in ApoE-/- mice

Research progress of nanomedical drug delivery system based on aerobic glycolytic regulation for tumor therapy

Analysis of the mechanisms of Guanxinning Tablet for antithrombotic and microthrombotic effects caused by COVID-19 based on network pharmacology

The effect and mechanism of Lycium barbarum leaves on D-galactose-induced cataract in rats based on metabolomics

Chemical constituents of dichloromethane extract from the stems of Ephedra intermedia

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