Yaoxue Xuebao

YX-25-02-2025-2148
| Yaoxue Xuebao (ISSN:0513-4870)

Bifunctional molecules from viewpoint of medicinal chemistry

Therapeutic radiopharmaceuticals have been researched extensively in the last decade as a result of the growing research interest in personalized medicine to improve diagnostic accuracy and intensify intensive therapy while limiting side effects. Radiometal-based drugs are of substantial interest because of their greater versatility for clinical translation compared to non-metal radionuclides. This paper comprehensively discusses various components commonly used as chemical scaffolds to build radiopharmaceutical agents, i.e., radionuclides, pharmacokinetic-modifying linkers, and chelators,

YX-25-02-2025-2147
| Yaoxue Xuebao (ISSN:0513-4870)

Advances of antibody drug conjugates in pancreatic cancer therapy

Antibody–drug conjugates (ADCs) are novel drugs that exploit the specificity of a monoclonal antibody (mAb) to reach target antigens expressed on cancer cells for the delivery of a potent cytotoxic payload. ADCs provide a unique opportunity to deliver drugs to tumor cells while minimizing toxicity to normal tissue, achieving wider therapeutic windows and enhanced pharmacokinetic/pharmacodynamic properties. To date, nine ADCs have been approved by the FDA and more than 80 ADCs are under clinical development worldwide. In this paper, we provide an overview of the biology and chemistry o

YX-25-02-2025-2146
| Yaoxue Xuebao (ISSN:0513-4870)

Preliminary study of the transport and absorption mechanism of Astragalus polysaccharide-II on M cells

Astragali radix (AR) is one of the most widely used traditional Chinese herbal medicines. Modern pharmacological studies and clinical practices indicate that AR possesses various biological functions, including potent immunomodulation, antioxidant, anti-inflammation and antitumor activities. To date, more than 200 chemical constituents have been isolated and identified from AR. Among them, isoflavonoids, saponins and polysaccharides are the three main types of beneficial compounds responsible for its pharmacological activities and therapeutic efficacy. After ingestion of AR, the metabolism

YX-25-02-2025-2145
| Yaoxue Xuebao (ISSN:0513-4870)

Advances in host protease-mediated influenza virus entry

TMPRSS2, a human transmembrane protease enzyme, plays a crucial role in the spread of certain viruses, including influenza and coronaviruses. This enzyme promotes viral infection by cleaving viral glycoproteins, which helps viruses like SARS-CoV-2 and influenza A enter cells more effectively. Genetic differences in TMPRSS2 may affect people’s susceptibility to COVID-19, underscoring the need for studies that consider diverse populations. Beyond infectious diseases, TMPRSS2 has also been linked to some cancers, suggesting it could be a valuable target for drug development. This review

YX-25-02-2025-2144
| Yaoxue Xuebao (ISSN:0513-4870)

Cloning and interacted protein identification of AP1 homologous gene from Lonicera macranthoides

To clone the AP1 (Lm-XL-AP1) gene from a Special Variant Varieties of Lonicera macranthoides "Xianglei", and to analyze its bioinformatics and spatio-temporal expression. Amplifing the full length of Lm-XL-AP1 gene by RACE technique, using bioinformatics method to analyze homology and similarity of the gene, predicting the coding protein and analyzing the various physical and chemical properties. The expression of the gene in different parts of Lonicera macranthoides Special Variant Varieties was detected by fluorescence quantitative PCR (qRT-PCR). The AP1 gene, containing a 729 b

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Yaoxue Xuebao

Bifunctional molecules from viewpoint of medicinal chemistry

Advances of antibody drug conjugates in pancreatic cancer therapy

Preliminary study of the transport and absorption mechanism of Astragalus polysaccharide-II on M cells

Advances in host protease-mediated influenza virus entry

Cloning and interacted protein identification of AP1 homologous gene from Lonicera macranthoides

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