Yaoxue Xuebao

YX-25-02-2025-2150
| Yaoxue Xuebao (ISSN:0513-4870)

Study on multi-component contents of Jinqi Jiangtang Capsule

Natural deep eutectic solvents (NADESs), composed of natural primary metabolites, are now widely used as green and sustainable extraction solvents of bioactive components. In the present study, various NADESs were prepared to extract multi-components from different preparations of an herbal formula (Chinese name: Jinqi Jiangtang, JQJT) using ultrasound-assisted extraction (UAE). Results showed that most prepared NADESs provided more effective extraction of phenolic acids and alkaloids from JQJT preparations than conventional solvents. Among the tested NADESs, the solvent formed by choline c

YX-25-02-2025-2149
| Yaoxue Xuebao (ISSN:0513-4870)

Analysis of the proposal application and funding of National Natural Science Foundation of China in the field of synthetic medicinal chemistry in 2023

The discovery and advances of medicines may be considered as the ultimate relevant translational science effort that adds to human invulnerability and happiness. But advancing a fresh medication is a quite convoluted, costly, and protracted operation, normally costing USD ~2.6 billion and consuming a mean time span of 12 years. Methods to cut back expenditure and hasten new drug discovery have prompted an arduous and compelling brainstorming exercise in the pharmaceutical industry. The engagement of Artificial Intelligence (AI), including the deep-learning (DL) component in particular, has

YX-25-02-2025-2148
| Yaoxue Xuebao (ISSN:0513-4870)

Bifunctional molecules from viewpoint of medicinal chemistry

Therapeutic radiopharmaceuticals have been researched extensively in the last decade as a result of the growing research interest in personalized medicine to improve diagnostic accuracy and intensify intensive therapy while limiting side effects. Radiometal-based drugs are of substantial interest because of their greater versatility for clinical translation compared to non-metal radionuclides. This paper comprehensively discusses various components commonly used as chemical scaffolds to build radiopharmaceutical agents, i.e., radionuclides, pharmacokinetic-modifying linkers, and chelators,

YX-25-02-2025-2147
| Yaoxue Xuebao (ISSN:0513-4870)

Advances of antibody drug conjugates in pancreatic cancer therapy

Antibody–drug conjugates (ADCs) are novel drugs that exploit the specificity of a monoclonal antibody (mAb) to reach target antigens expressed on cancer cells for the delivery of a potent cytotoxic payload. ADCs provide a unique opportunity to deliver drugs to tumor cells while minimizing toxicity to normal tissue, achieving wider therapeutic windows and enhanced pharmacokinetic/pharmacodynamic properties. To date, nine ADCs have been approved by the FDA and more than 80 ADCs are under clinical development worldwide. In this paper, we provide an overview of the biology and chemistry o

YX-25-02-2025-2146
| Yaoxue Xuebao (ISSN:0513-4870)

Preliminary study of the transport and absorption mechanism of Astragalus polysaccharide-II on M cells

Astragali radix (AR) is one of the most widely used traditional Chinese herbal medicines. Modern pharmacological studies and clinical practices indicate that AR possesses various biological functions, including potent immunomodulation, antioxidant, anti-inflammation and antitumor activities. To date, more than 200 chemical constituents have been isolated and identified from AR. Among them, isoflavonoids, saponins and polysaccharides are the three main types of beneficial compounds responsible for its pharmacological activities and therapeutic efficacy. After ingestion of AR, the metabolism

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Yaoxue Xuebao

Study on multi-component contents of Jinqi Jiangtang Capsule

Analysis of the proposal application and funding of National Natural Science Foundation of China in the field of synthetic medicinal chemistry in 2023

Bifunctional molecules from viewpoint of medicinal chemistry

Advances of antibody drug conjugates in pancreatic cancer therapy

Preliminary study of the transport and absorption mechanism of Astragalus polysaccharide-II on M cells

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