Yaoxue Xuebao

YX-18-11-2024-2107
| Yaoxue Xuebao (ISSN:0513-4870)

Research methods of miRNA in plants and research progress of miRNA in medicinal plants

microRNA (miRNA) is a class of endogenous ~21nt non-coding single-strand small RNAs which play important roles in plant growth and development, signal transduction, stress response, and secondary metabolism. In recent years, a large number of miRNAs have been identified in various medicinal plants, and the regulatory effects of these miRNAs have been preliminarily studied. In medicinal plants, most of the active components are secondary metabolites, so it is of great significance to study the regulatory effects of miRNA on the formation of secondary metabolites. In this paper, the general r

YX-18-11-2024-2106
| Yaoxue Xuebao (ISSN:0513-4870)

Current drug research on intestinal mucosal healing in inflammatory bowel disease based on macrophage regulation

Complete healing of the intestinal mucosa is the most ideal goal in the treatment of inflammatory bowel disease (IBD). The intestinal mucosa healing not only significantly alters the course of the disease and relieves clinical symptoms, but also markedly reduces the occurrence of complications and prevents recurrence of IBD. As chronic inflammation associated with peptic ulcer damage is the main pathological feature of IBD, clinical treatment is mainly based on anti-inflammatory therapy, but such therapy cannot promote the healing of the intestinal mucosa of patients. Therefore, how to achi

YX-18-11-2024-2105
| Yaoxue Xuebao (ISSN:0513-4870)

Comparative analysis of chemical constituents in hawthorn leaves from different sources

We identified and analyzed the components and chemical constituents of hawthorn leaves of Crataegus pinnatifida Bge. (wild) and C. pinnatifida Bge. var major NE Br (cultivated) by using ultra high-performance liquid chromatography and quadrupole time-of-flight mass spectrometry (UHPLC-Q-TOF/MSE) combined with UNIFI data analysis platform and multivariate statistics. Fifty-eight chemical compounds were identified, including organic acids, flavonoids, triterpenoic acids, monoterpenes and sesquiterpenoids; among them, terpenoid content was the most abundant. Principal component analysis (PCA)

YX-18-11-2024-2104
| Yaoxue Xuebao (ISSN:0513-4870)

Research progress of febuxostat derivatives as xanthine oxidase inhibitors

Febuxostat, as a xanthine oxidase inhibitor, is a classic anti-gout drug with significant therapeutic effects and good tolerability. The structures of febuxostat and its derivatives can be divided into two parts: a substituted phenyl ring and a five-membered or six-membered heterocyclic ring with a carboxyl substitution. This paper reviewed the research progress of febuxostat derivatives in recent ten years and classified the structure-activity relationships of various febuxostat derivatives. Exploring the action mechanisms and structure-activity relationships of xanthine oxidase inhibitors

YX-19-10-2024-2103
| Yaoxue Xuebao (ISSN:0513-4870)

Research Progress of Human Gut Microbiome for Forensic Personal Characterization

Human intestinal tract accommodates the most varieties and quantity of microbes in human body, establishing the colonies of bacteria, viruses, fungi, archaea and eukaryotes that have come into being the so-called human gut microbiome (HGM). Evidently, HGM is characteristic of enormous amount of microbes, long-duration stability and liability of individual specificity, hence making it promising to arise as a novel biomarker for forensic personal identification. Factually, the explosion of microbiomics research occurred along with the availability of high-throughput sequencing in the last dec

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Yaoxue Xuebao

Yaoxue Xuebao

Pharmacology

Toxicology and Pharmaceutics

General Pharmacology

Toxicology and Pharmaceutics Biochemistry

Genetics and Molecular Biology

Molecular Medicine

Yaoxue Xuebao

Research methods of miRNA in plants and research progress of miRNA in medicinal plants

Current drug research on intestinal mucosal healing in inflammatory bowel disease based on macrophage regulation

Comparative analysis of chemical constituents in hawthorn leaves from different sources

Research progress of febuxostat derivatives as xanthine oxidase inhibitors

Research Progress of Human Gut Microbiome for Forensic Personal Characterization

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