Yaoxue Xuebao

YX-18-11-2024-2112
| Yaoxue Xuebao (ISSN:0513-4870)

Study of intermolecular interactions of piroxicam polymorphs

Piroxicam has polymorphism. Different crystalline forms can exhibit different physicochemical properties and biological activities. Analysis of the intermolecular interactions is essential to reveal the formation mechanism and differences of polymorphs. In this paper, Hirshfeld surface analysis and semi-empirical methods were used to calculate and analyze the intermolecular interactions in seven polymorphic forms of piroxicam. The results show that the Hirshfeld surface analysis method can clearly and intuitively reveal the intermolecular interactions, among which H…H, O…H/H&h

YX-18-11-2024-2111
| Yaoxue Xuebao (ISSN:0513-4870)

Research progress of cystic fibrosis and its therapies

Cystic fibrosis (CF) is a common and life-threatening autosomal recessive disorder in Caucasian populations. The disease is caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene. The absence of mature CFTR at the correct cellular location or dysfunction of CFTR proteins has been observed in CF patients. CF is frequently accompanied by a variety of complex complications, such as impairments in pulmonary functions, which may lead to successive infections and respiratory failure. Recently, with the understanding of the pathogenesis of CF, a wide array of th

YX-18-11-2024-2110
| Yaoxue Xuebao (ISSN:0513-4870)

Research progress in clinical treatment of Alzheimer's disease and potential drugs from natural products

With the acceleration of the aging process of our country's population, the impact of aging-related diseases - Alzheimer's disease (AD) on society and families has become increasingly prominent. AD is caused by multiple mechanisms, and the pathogenesis has not been fully elucidated. Most of the clinical treatments are single therapy, which mainly focuses on improving symptoms and are difficult to reverse the disease process. Therefore, the development of drugs that can both improve symptoms and reverse the disease process is extremely urgent in clinical. Increasing number of studies

YX-18-11-2024-2109
| Yaoxue Xuebao (ISSN:0513-4870)

The development of folate modified squalene-chidamide prodrug self-assembled nanoparticles to enhance the drug delivery in pancreatic cancer microenvironment

This research aimed at the key issue that chemical drugs and Chinese medicine hydrophilic small molecule anti-tumor drugs were difficult to break through the dense interstitial permeability barrier of pancreatic cancer to achieve the key problem of drug efficacy in the deep part of tumor tissue. To solve this problem, the lipophilic molecule squalene (SQ) and the hydrophilic anti-tumor drug chidamide (CHI) were linked by a trypsin responsive bond to form a prodrug (SQ-CHI) and a folic acid modified prodrug self-assembled nanoparticles (FA-SQ-CHI NPs) were further developed. The feature of p

YX-18-11-2024-2108
| Yaoxue Xuebao (ISSN:0513-4870)

Transcriptome analysis to identify genes involved in the biosynthesis of aconitines in aconitum pendulum

italic>Aconitum pendulum is a Tibetan medicine that is rich in bioactive compounds such as aconitine-type C19-diterpenoid alkaloids. To investigate the key enzymes in the aconitine biosynthesis pathway, roots, leaves and flowers of Aconitum pendulum were subjected to a high-throughput transcriptomic sequencing analysis by Illumina HiSeqTM2000. Trinity de novo assembly yielded 47,264 unigenes with an average length of 1,140 bp and N50 of 1,678 bp, of which 30,231 unigenes (63.96%) were annotated. In the KEGG database, 542 unigenes were implicated in 17 secondary metabolic pathways; the an

Yaoxue Xuebao

Dear respected authors,

If you can't find our response by email, please check your spam box as well as communicate with us to the following mail as well: journalpublication435@gmail.com

Yaoxue Xuebao

Yaoxue Xuebao

Pharmacology

Toxicology and Pharmaceutics

General Pharmacology

Toxicology and Pharmaceutics Biochemistry

Genetics and Molecular Biology

Molecular Medicine

Yaoxue Xuebao

Study of intermolecular interactions of piroxicam polymorphs

Research progress of cystic fibrosis and its therapies

Research progress in clinical treatment of Alzheimer's disease and potential drugs from natural products

The development of folate modified squalene-chidamide prodrug self-assembled nanoparticles to enhance the drug delivery in pancreatic cancer microenvironment

Transcriptome analysis to identify genes involved in the biosynthesis of aconitines in aconitum pendulum

Information

Guidelines

Contact Us

All rights reserved | © 2024 Yaoxue Xuebao (ISSN:0513-4870).