Yaoxue Xuebao

YX-18-11-2024-2115
| Yaoxue Xuebao (ISSN:0513-4870)

Characterization and phylogenetic analysis of the complete chloroplast genome of Lycopus europaeus

We intend to study the structural characteristics of Lycopus europaeus Linn. chloroplast genome and compare the evolutionary relationship of species from Lamiaceae with similar medicinal effects. The total DNA of Lycopus europaeus was sequenced using the Illumina Hiseq 4000 Sequencing platform and was assembled using NOVOplasty software. And then we annotated and analyzed the genome using the CPGAVAS2 online tool. We constructed the phylogenetic tree using the Stellera chamaejasme and Potentilla chinensis as the outgroup. The entire length of Lycopus europaeus chloroplast genome was 152 085

YX-18-11-2024-2113
| Yaoxue Xuebao (ISSN:0513-4870)

Research on the antioxidant activity of metabolites from a sponge-derived fungus Alternaria sp.

To study the chemical constituents from the deep-sea fungus Alternaria sp. F49. Seven compounds were isolated from the EtOAc extract by using silica gel, Sephadex LH-20, ODS and HPLC methods. Based on the spectroscopic analysis, their structures were identified as (8R)-5-O-methyl-orcinotriol (1), orcinotriol (2), α-acetylorcinol (3), 3'-hydroxyalternariol 5-O-methyl ether (4), altenusiol (5), altenusin (6), and 5'-methoxy-6-methyl-biphenyl-3,4,3'-triol (7). (8R)-5-O-Methyl-orcinotriol (1) is a new phenolic compound which has never been reported in the literature. Compounds

YX-18-11-2024-2112
| Yaoxue Xuebao (ISSN:0513-4870)

Study of intermolecular interactions of piroxicam polymorphs

Piroxicam has polymorphism. Different crystalline forms can exhibit different physicochemical properties and biological activities. Analysis of the intermolecular interactions is essential to reveal the formation mechanism and differences of polymorphs. In this paper, Hirshfeld surface analysis and semi-empirical methods were used to calculate and analyze the intermolecular interactions in seven polymorphic forms of piroxicam. The results show that the Hirshfeld surface analysis method can clearly and intuitively reveal the intermolecular interactions, among which H…H, O…H/H&h

YX-18-11-2024-2111
| Yaoxue Xuebao (ISSN:0513-4870)

Research progress of cystic fibrosis and its therapies

Cystic fibrosis (CF) is a common and life-threatening autosomal recessive disorder in Caucasian populations. The disease is caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene. The absence of mature CFTR at the correct cellular location or dysfunction of CFTR proteins has been observed in CF patients. CF is frequently accompanied by a variety of complex complications, such as impairments in pulmonary functions, which may lead to successive infections and respiratory failure. Recently, with the understanding of the pathogenesis of CF, a wide array of th

YX-18-11-2024-2110
| Yaoxue Xuebao (ISSN:0513-4870)

Research progress in clinical treatment of Alzheimer's disease and potential drugs from natural products

With the acceleration of the aging process of our country's population, the impact of aging-related diseases - Alzheimer's disease (AD) on society and families has become increasingly prominent. AD is caused by multiple mechanisms, and the pathogenesis has not been fully elucidated. Most of the clinical treatments are single therapy, which mainly focuses on improving symptoms and are difficult to reverse the disease process. Therefore, the development of drugs that can both improve symptoms and reverse the disease process is extremely urgent in clinical. Increasing number of studies

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Pharmacology

Toxicology and Pharmaceutics

General Pharmacology

Toxicology and Pharmaceutics Biochemistry

Genetics and Molecular Biology

Molecular Medicine

Yaoxue Xuebao

Characterization and phylogenetic analysis of the complete chloroplast genome of Lycopus europaeus

Research on the antioxidant activity of metabolites from a sponge-derived fungus Alternaria sp.

Study of intermolecular interactions of piroxicam polymorphs

Research progress of cystic fibrosis and its therapies

Research progress in clinical treatment of Alzheimer's disease and potential drugs from natural products

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